Invitrogen

FGFR3 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
FGFR3 Polyclonal Antibody

Product Details

PA5-87432

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 700-806 of human FGFR3 (NP_0001331)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804142

Product Specific Information

Positive Samples: U-87MG, A-549, A-431; Cellular Location: Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Single-pass type I membrane protein

Immunogen sequence: VEELFKLLKE GHRMDKPANC THDLYMIMRE CWHAAPSQRP TFKQLVEDLD RVLTVTSTDE YLDLSAPFEQ YSPGGQDTPS SSSSGDDSVF AHDLLPPAPP SSGGSRT

Target Information

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD333; FGF Receptor; FGFR; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; tyrosine kinase JTK4

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Gene Aliases: ACH; CD333; CEK2; Fgfr-3; FGFR3; Flg-2; FR3; HBGFR; HSFGFR3EX; JTK4; Mfr3; sam3

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UniProt ID: (Human) P22607

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Entrez Gene ID: (Human) 2261, (Rat) 84489, (Mouse) 14184

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Function(s)
protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity growth factor activity nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
MAPK cascade skeletal system development endochondral ossification chondrocyte differentiation endochondral bone growth JAK-STAT cascade cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation bone mineralization chondrocyte proliferation phosphatidylinositol-3-phosphate biosynthetic process positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of MAPK cascade positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling negative regulation of developmental growth bone morphogenesis positive regulation of ERK1 and ERK2 cascade bone maturation fibroblast growth factor receptor apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter positive regulation of endothelial cell proliferation morphogenesis of an epithelium lens morphogenesis in camera-type eye negative regulation of cell proliferation oligodendrocyte development substantia nigra development central nervous system myelination cell differentiation forebrain development positive regulation of protein ubiquitination somatic stem cell population maintenance post-anal tail morphogenesis positive regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of mitotic nuclear division negative regulation of smoothened signaling pathway digestive tract morphogenesis response to axon injury negative regulation of astrocyte differentiation inner ear development negative regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cartilage development inner ear receptor cell differentiation axonogenesis involved in innervation alveolar secondary septum development lens fiber cell development epithelial cell fate commitment positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway cochlea development positive regulation of canonical Wnt signaling pathway protein phosphorylation apoptotic process phosphorylation
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