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FGFR1OP2 Polyclonal Antibody
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Product Details
BS-8346R
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Shipping conditions
Target Information
FGFR1OP2, also known as FGFR1 oncogene partner 2, is a gene that plays a crucial role in oncogenesis, particularly in myeloproliferative neoplasms. It is known to interact with the FGFR1 (Fibroblast Growth Factor Receptor 1) through chromosomal translocations that can lead to malignancies, such as the formation of the fusion protein FGFR1OP2-FGFR1 in KG-1a leukemic cells. FGFR1OP2 itself is a gene encoding a protein whose function is not entirely understood, but its association with FGFR1 highlights its potential role in oncogenic pathways. The FGFR1 component of the fusion is a receptor tyrosine kinase involved in various cellular processes like cell proliferation, migration, and differentiation. The disruption of these processes through abnormal expression or structural changes such as fusions can lead to uncontrolled cell growth and malignancies. FGFR1 is also frequently studied as a therapeutic target in cancer, given its importance in cellular signaling and cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FGFR1 oncogene partner 2; FGFR1 oncogene partner 2 homolog; fibroblast growth factor receptor 1 oncogene partner 2; Wit3.0; Wit3.0_alpha; Wit3.0_beta; wound inducible transcript 3.0; wound inducible transcript 3.0 protein; Wound-inducible transcript 3.0 protein
Gene Aliases: 1500031J01Rik; FGFR1OP2; HSPC123; HSPC123-like; WIT3.0
UniProt ID: (Human) Q9NVK5, (Mouse) Q9CRA9, (Rat) Q6TA25
Entrez Gene ID: (Human) 26127, (Mouse) 67529, (Rat) 362463
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