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NeoBiotechnologies
ETS1 (Marker of Tumor Metastasis) Monoclonal Antibody (ETS1/1801)
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FIGURE: 1 / 2
ETS1 (Marker of Tumor Metastasis) Antibody (2113-MSM1-P0) in ARRAY
Product Details
2113-MSM1-P0
Species Reactivity
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Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1
Gene Aliases: c-ets-1; ETS-1; ETS1; EWSR2; p54
UniProt ID: (Human) P14921
Entrez Gene ID: (Human) 2113
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