NeoBiotechnologies

ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ESR2/686)

View all (57) Estrogen Receptor beta antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

2100-MSM2-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

ESR2/686

Immunogen

C-terminus fragment of recombinant human estrogen receptor beta protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Wet ice

Target Information

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ER; ER beta; ER-beta; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2

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Gene Aliases: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2

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UniProt ID: (Human) Q92731

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Entrez Gene ID: (Human) 2100

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Function(s)
core promoter sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding drug binding zinc ion binding enzyme binding estrogen receptor activity estrogen response element binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding peroxisome proliferator activated receptor binding receptor antagonist activity estradiol binding steroid hormone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development behavioral fear response regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter signal transduction cell-cell signaling learning or memory response to water deprivation response to activity response to insecticide cerebellum development amygdala development hypothalamus development negative regulation of cell growth intracellular estrogen receptor signaling pathway prostate gland development response to nutrient levels response to testosterone response to genistein cellular response to drug positive regulation of apoptotic process regulation of neuron apoptotic process response to estrogen response to human chorionic gonadotropin estrous cycle response to ethanol positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity Sertoli cell development Sertoli cell proliferation positive regulation of ERK1 and ERK2 cascade cellular response to magnetism cellular response to estradiol stimulus response to dexamethasone extracellular negative regulation of signal transduction negative regulation of neuron death response to salt response to bisphenol A negative regulation of feeding behavior negative regulation of reactive oxygen species metabolic process
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