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Proteintech
EHD3 Polyclonal Antibody
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Product Details
25320-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: FPNLKRMQD QLQAQDFSKF QPLKSKLLEV VDDMLAHDIA QLMVLVRQEE SQRPIQMVKG GAFEGTLHGP F (353-422 aa encoded by BC156996)
Target Information
The EHD3 gene encodes the EH-domain containing protein 3, part of the EHD protein family involved in the regulation of endocytic recycling and membrane trafficking. EHD3 plays a crucial role in the endosomal transport system, impacting how receptors and other membrane proteins are recycled back to the cell surface after internalization. This protein aids in maintaining cellular homeostasis by ensuring the efficient sorting and transport of cargo through the endosomal system. EHD3 has been implicated in various cellular functions, including insulin signaling, receptor recycling, and neuronal development, and significantly influences synaptic transmission and plasticity. Alterations in EHD3 expression or function can disrupt endosomal trafficking processes and are linked to conditions such as neurodegenerative diseases and cancer. Research on EHD3 is focused on uncovering its role in membrane dynamics and identifying potential therapeutic strategies for disorders involving dysfunctional endocytic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EH domain-containing protein 3; EH-domain containing 3; EH-domain containing protein 2; PAST homolog 3
Gene Aliases: EHD2; EHD3; PAST3
UniProt ID: (Human) Q9NZN3, (Rat) Q8R491, (Mouse) Q9QXY6
Entrez Gene ID: (Human) 30845, (Rat) 192249, (Mouse) 57440
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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