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EGR1 Monoclonal Antibody (6E8)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
EGR1 Monoclonal Antibody (6E8)

Product Details

H00001958-M03

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL
-

Immunocytochemistry (ICC/IF)

10-100 µg/mL
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

6E8

Immunogen

EGR1 (NP_001955, 444 a.a. approximately 543 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

Immunogen sequence: SPVATSYPSP VTTSYPSPAT TSYPSPVPTS FSSPGSSTYP SPVHSGFPSP SVATTYSSVP PAFPAQVSSF PSSAVTNSFS ASTGLSDMTA TFSPRTIEIC

Target Information

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT225; Early growth response protein 1; EGR-1; Krox-24 nuclear protein; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24

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Gene Aliases: A530045N19Rik; AT225; egr; Egr-1; EGR1; ETR103; G0S30; Krox-1; KROX-24; KROX24; Ngf1; NGF1-A; Ngfi; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; ZIF-268; Zif268; ZNF225

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UniProt ID: (Human) P18146, (Rat) P08154, (Mouse) P08046

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Entrez Gene ID: (Human) 1958, (Rat) 24330, (Mouse) 13653

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone acetyltransferase binding sequence-specific DNA binding metal ion binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding double-stranded DNA binding transcription factor binding transcription regulatory region DNA binding nucleic acid binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to glucose T cell differentiation BMP signaling pathway response to insulin regulation of protein sumoylation skeletal muscle cell differentiation regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway cellular response to gamma radiation cellular response to heparin cellular response to mycophenolic acid glomerular mesangial cell proliferation positive regulation of glomerular metanephric mesangial cell proliferation negative regulation of canonical Wnt signaling pathway response to amphetamine regulation of transcription, DNA-templated learning or memory circadian rhythm positive regulation of gene expression positive regulation of cell death response to nutrient levels response to follicle-stimulating hormone cellular response to insulin stimulus response to carbon monoxide response to gonadotropin cellular response to drug response to cocaine response to drug negative regulation of apoptotic process positive regulation of neuron apoptotic process response to ethanol regulation of long-term neuronal synaptic plasticity oligodendrocyte differentiation response to electrical stimulus long-term synaptic potentiation cellular response to antibiotic cellular response to mechanical stimulus cellular response to organic substance cellular response to isoquinoline alkaloid cellular response to cAMP cellular response to growth factor stimulus cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus cellular response to hyperoxia cellular response to hypoxia response to norepinephrine transcription, DNA-templated
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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