OriGene

DVL2 Monoclonal Antibody (OTI7F10), TrueMAB™

Name: DVL2 Monoclonal Antibody (OTI7F10), TrueMAB\u2122
Brand: OriGene
SKU: CF806918

View all (29) DVL2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

FIGURE: 1 / 1

DVL2 Antibody (CF806918) in WB

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DVL2 (RC202233, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DVL2. Positive lysates LY401405 (100 µg) and LC401405 (20 µg) can be purchased separately from OriGene.

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Immunogen Image DVL2 Monoclonal Antibody (OTI7F10), TrueMAB™

Product Details

CF806918

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI7F10

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-320 of human DVL2 produced in E.coli.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2

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Gene Aliases: DVL2

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UniProt ID: (Human) O14641

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Entrez Gene ID: (Human) 1856

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Function(s)

frizzled binding protein binding protein kinase binding protein domain specific binding protein binding, bridging identical protein binding protein self-association Rac GTPase binding

Process(es)

neural tube closure positive regulation of protein phosphorylation outflow tract morphogenesis transcription from RNA polymerase II promoter segment specification heart development Wnt signaling pathway convergent extension involved in neural plate elongation cellular protein localization hippo signaling non-canonical Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of GTPase activity canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity protein oligomerization canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway positive regulation of protein tyrosine kinase activity negative regulation of canonical Wnt signaling pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex disassembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DVL2 Monoclonal Antibody (OTI7F10), TrueMAB™

DVL2 Antibody (CF806918) in WB

Product Details

CF806918

Western Blot (WB)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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