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  • Primary Antibodies ›
  • DLC1 Antibodies

Invitrogen

DLC1 Polyclonal Antibody

View all (15) DLC1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite DLC1 Polyclonal Antibody

  • Antibody Testing Data (5)
DLC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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DLC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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DLC1 Antibody (PA5-106902) in IHC (P)

Immunohistochemistry analysis of DLC1 in rat liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DLC1 polyclonal antibody (Product # PA5-106902) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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DLC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
DLC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
DLC1 Antibody in Western Blot (WB)
DLC1 Antibody in Western Blot (WB)
DLC1 Antibody in Western Blot (WB)
DLC1 Polyclonal Antibody

Product Details

PA5-106902

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DLC1(Accession Q96QB1), corresponding to amino acid residues N51-E101.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854566

Product Specific Information

Antibody detects endogenous levels of total DLC1.

Target Information

This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ARHGAP 7; Deleted in liver cancer 1 protein; Deleted in liver cancer 1 protein homolog; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; DLC 1; DLC-1; FLJ21120; HP protein; p122 RhoGAP; p122-RhoGAP; rho GTPase activating protein 7; Rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StAR-related lipid; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; STARD 12; StARD12; START domain-containing protein 12; transfer protein 12

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Gene Aliases: A730069N07Rik; ARHGAP7; dlc-1; DLC1; HP; KIAA1723; p122-RhoGAP; RhoGAP; STARD12

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UniProt ID: (Human) Q96QB1, (Mouse) Q3TRX3

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Entrez Gene ID: (Human) 10395, (Mouse) 50768, (Rat) 58834

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Function(s)
GTPase activator activity protein binding lipid binding SH2 domain binding vinculin binding phospholipase binding
Process(es)
neural tube closure heart morphogenesis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cytoskeleton organization signal transduction activation of phospholipase C activity negative regulation of cell proliferation regulation of cell shape hindbrain morphogenesis actin cytoskeleton organization negative regulation of cell migration forebrain development regulation of actin cytoskeleton organization regulation of Rho protein signal transduction negative regulation of Rho protein signal transduction positive regulation of protein dephosphorylation positive regulation of GTPase activity focal adhesion assembly negative regulation of stress fiber assembly negative regulation of focal adhesion assembly positive regulation of execution phase of apoptosis regulation of small GTPase mediated signal transduction Rho protein signal transduction cellular response to insulin stimulus
It has to be done as per old AB suggested Products section.
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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