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NeoBiotechnologies
DAZL (Deleted in Azoospermia-like) Monoclonal Antibody (DAZL/4253)
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Product Details
1618-MSM1-P1ABX
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Target Information
Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DAZ homolog; DAZ-like autosomal; deleted in azoospermia protein 3; Deleted in azoospermia-like; Deleted in azoospermia-like 1; germline specific RNA binding protein; HGNC:2685; MGC26406; RNA-binding protein; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; testis secretory sperm-binding protein Li 204a
Gene Aliases: cynDAZLA; Daz-like; DAZH; DAZL; DAZL1; DAZLA; SPGYLA; Tpx-2; Tpx2
UniProt ID: (Cynomolgus monkey) Q95192, (Human) Q92904, (Mouse) Q64368
Entrez Gene ID: (Cynomolgus monkey) 102121570, (Human) 1618, (Mouse) 13164, (Rat) 680486
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