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Invitrogen
Cyclin A Polyclonal Antibody
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FIGURE: 1 / 11
Cyclin A Antibody (PA5-104254) in ICC/IF
Product Details
PA5-104254
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Antibody detects endogenous levels of total Cyclin A1.
Target Information
The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cyclin A; Cyclin A2 (Cyclin A); Cyclin-A; Cyclin-A1; Cyclin-A2; CyclinA; CyclinA1; testicular tissue protein Li 34
Gene Aliases: AA408589; Ccn-1; CCN1; CCNA; CCNA1; CCNA2; CT146; Cyca; CycA2
UniProt ID: (Human) P78396, (Human) P20248, (Rat) Q6AY13, (Mouse) Q61456, (Mouse) P51943
Entrez Gene ID: (Human) 8900, (Human) 890, (Rat) 295052, (Mouse) 12427, (Rat) 114494, (Mouse) 12428
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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