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  • CXCR2 Antibodies

Proteintech

Cxcr2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers

Cite Cxcr2 Polyclonal Antibody

  • Antibody Testing Data (2)
Cxcr2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Cxcr2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Cxcr2 Antibody (19538-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 19538-1-AP (Il8rb-Specific antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Cxcr2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Cxcr2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Details

19538-1-AP

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; chemokine (C-X-C) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor alpha chain; Il-8 receptor b; IL-8 receptor beta; IL-8R B; interleukin 8 receptor, beta; interleukin-8 receptor type B

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Gene Aliases: CD128; CDw128; Cmkar2; Cxcr2; Gpcr16; IL-8rb; IL-8Rh; IL8RA; Il8rb; mIL-8RH

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UniProt ID: (Mouse) P35343

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Entrez Gene ID: (Mouse) 12765

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Function(s)
signal transducer activity interleukin-8 receptor activity G-protein coupled receptor activity chemokine receptor activity protein binding C-X-C chemokine receptor activity interleukin-8 binding
Process(es)
acute inflammatory response to antigenic stimulus positive regulation of leukocyte chemotaxis chemotaxis cellular defense response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation positive regulation of cardiac muscle cell apoptotic process neutrophil chemotaxis receptor internalization negative regulation of neutrophil apoptotic process interleukin-8-mediated signaling pathway neutrophil activation negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of angiogenesis chemokine-mediated signaling pathway metanephric tubule morphogenesis positive regulation of neutrophil chemotaxis
It has to be done as per old AB suggested Products section.
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