Proteintech

Collagen Type IV Polyclonal Antibody

View all (45) Collagen IV antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (4)

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

Collagen Type IV Antibody (55131-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using (Product # 55131-1-AP) (Collagen Type IV antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using (Product # 55131-1-AP) (Collagen Type IV antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human kidney tissue slide using (Product # 55131-1-AP) Collagen Type IV antibody at dilution of 1:1,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 55131-1-AP ( Collagen Type IV antibody at dilution of 1:50 (under 40x lens).

Collagen Type IV Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 55131-1-AP ( Collagen Type IV antibody at dilution of 1:50 (under 10x lens).

Product Details

55131-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 42 publications 42 publications

Immunohistochemistry (IHC)

-

View 20 publications 20 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

-

View 13 publications 13 publications

Miscellaneous PubMed (MISC)

-

View 1 publication 1 publication

Not applicable (N/A)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific for collagen, type IV, alpha.

Target Information

Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.

Advances in rheumatology (London, England)

Wang D,Wei Y,Xu L,Zhang J

Tue May 16 00:00:00 UTC 2023

Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.

Gastroenterology

Zuo T,Xie Q,Liu J,Yang J,Shi J,Kong D,Wang Y,Zhang Z,Gao H,Zeng DB,Wang X,Tao P,Wei W,Wang J,Li Y,Long Q,Li C,Chang L,Ning H,Li Y,Cui C,Ge X,Wu J,Li G,Hong X,Yang X,Dai E,He F,Wu J,Ruan Y,Lu S,Xu P

Fri Sep 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 UTC 2023

Germline gain-of-function MMP11 variant results in an aggressive form of colorectal cancer.

International journal of cancer

Martin-Morales L,Manzano S,Rodrigo-Faus M,Vicente-Barrueco A,Lorca V,Núñez-Moreno G,Bragado P,Porras A,Caldes T,Garre P,Gutierrez-Uzquiza A

Sun Jan 15 00:00:00 UTC 2023

Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.

Molecular and cellular biochemistry

Hu Z,Zhang Y,Chen J,Luo M,Wang N,Xiao Y,He Q

Tue Aug 01 00:00:00 UTC 2023

Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.

Molecular and cellular biochemistry

Hu Z,Zhang Y,Chen J,Luo M,Wang N,Xiao Y,He Q

Tue Aug 01 00:00:00 UTC 2023

Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Ye Z,Xian W,Ling GU,Zihang LI,Jingtian Z,Wenkai W,Liang Z,Mei X

Thu Jun 01 00:00:00 UTC 2023

The kidney antifibrotic effects of 5,7,3',4',5'-pentamethoxyflavone from Bauhinia championii in streptozotocin-induced diabetic rats: in vivo and in vitro experiments.

Pharmaceutical biology

Li J,Huang X,He K,Wu S

Fri Dec 01 00:00:00 UTC 2023

USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.

European journal of pharmacology

Zhao X,He X,Wei W,Huang K

Mon May 15 00:00:00 UTC 2023

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.

Biomaterials

Shi M,Zhang J,Wang Y,Peng C,Hu H,Qiao M,Zhao X,Chen D

Fri Apr 01 00:00:00 UTC 2022

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.

Biomaterials

Shi M,Zhang J,Wang Y,Peng C,Hu H,Qiao M,Zhao X,Chen D

Fri Apr 01 00:00:00 UTC 2022

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.

Biomaterials

Shi M,Zhang J,Wang Y,Peng C,Hu H,Qiao M,Zhao X,Chen D

Fri Apr 01 00:00:00 UTC 2022

Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.

Biomaterials

Shi M,Zhang J,Wang Y,Peng C,Hu H,Qiao M,Zhao X,Chen D

Fri Apr 01 00:00:00 UTC 2022

Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.

ACS applied materials & interfaces

Li Y,Yang L,Hu F,Xu J,Ye J,Liu S,Wang L,Zhuo M,Ran B,Zhang H,Ye J,Xiao J

Wed Jun 08 00:00:00 UTC 2022

Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.

BioMed research international

Yan R,Zhang Y,Yang Y,Liu L,Liu L,Guo Z,Yu H,Wang Y,Guo B

Tue Jul 12 00:00:00 UTC 2022

Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.

BioMed research international

Yan R,Zhang Y,Yang Y,Liu L,Liu L,Guo Z,Yu H,Wang Y,Guo B

Tue Jul 12 00:00:00 UTC 2022

The IRE1/JNK signaling pathway regulates inflammation cytokines and production of glomerular extracellular matrix in the acute kidney injury to chronic kidney disease transition.

Molecular biology reports

Liang Y,Qu L,Liu Z,Liang L,Wang Y,Quan S,Wang Y,Tang L

Mon Aug 01 00:00:00 UTC 2022

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.

Cell death & disease

Ai K,Pan J,Zhang P,Li H,He Z,Zhang H,Li X,Li Y,Yi L,Kang Y,Wang Y,Xiang X,Chai X,Zhang D

Tue Feb 08 00:00:00 UTC 2022

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.

Cell death & disease

Ai K,Pan J,Zhang P,Li H,He Z,Zhang H,Li X,Li Y,Yi L,Kang Y,Wang Y,Xiang X,Chai X,Zhang D

Tue Feb 08 00:00:00 UTC 2022

TIPARP is involved in the regulation of intraocular pressure.

Communications biology

Zhang Y,Song M,Bi Y,Lei Y,Sun X,Chen Y

Mon Dec 19 00:00:00 UTC 2022

Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression.

Biochemical and biophysical research communications

Feng Y,Zhu G,Chen R,Shi G,Peng M,Zhou Y,Fu W,Zhou P

Thu Oct 20 00:00:00 UTC 2022

Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains.

Neuropathology : official journal of the Japanese Society of Neuropathology

Wakamatsu K,Chiba Y,Murakami R,Matsumoto K,Miyai Y,Kawauchi M,Yanase K,Uemura N,Ueno M

Fri Apr 01 00:00:00 UTC 2022

Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains.

Neuropathology : official journal of the Japanese Society of Neuropathology

Wakamatsu K,Chiba Y,Murakami R,Matsumoto K,Miyai Y,Kawauchi M,Yanase K,Uemura N,Ueno M

Fri Apr 01 00:00:00 UTC 2022

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork.

International journal of ophthalmology

Wei M,Chen LM,Huang ZY,Zhang GW,Guan HJ,Ji M

Sat Aug 27 00:00:00 UTC 2022

Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies.

Biomolecules

Sanchez MM,Tonmoy TI,Park BH,Morgan JT

Wed Dec 07 00:00:00 UTC 2022

Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.

Functional & integrative genomics

Xiong Y,Song X,Zu X,Chen M,He W,Qi L

Sat Oct 01 00:00:00 UTC 2022

Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma.

The Journal of clinical investigation

Fu H,Siggs OM,Knight LS,Staffieri SE,Ruddle JB,Birsner AE,Collantes ER,Craig JE,Wiggs JL,D'Amato RJ

Thu Dec 01 00:00:00 UTC 2022

Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis.

JCI insight

Tan X,Banerjee P,Liu X,Yu J,Lee S,Ahn YH,Creighton CJ,Kurie JM

Tue Jan 11 00:00:00 UTC 2022

Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xiao Y,Deng J,Li C,Gong X,Gui Z,Huang J,Zhang Y,Liu Y,Ye X,Li X

Mon Mar 01 00:00:00 UTC 2021

The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.

Frontiers in pharmacology

Yu Y,Liu X,Zhao Z,Xu Z,Qiao Y,Zhou Y,Qiao H,Zhong J,Dai J,Suo G

Fri Dec 24 00:00:00 UTC 2021

Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney.

Frontiers in pharmacology

Rong Q,Han B,Li Y,Yin H,Li J,Hou Y

Tue Jan 25 00:00:00 UTC 2022

Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.

European journal of medicinal chemistry

Liu K,Zhao X,Qi X,Hou DL,Li HB,Gu YH,Xu QL

Sat Jun 05 00:00:00 UTC 2021

Engineering microvasculature by 3D bioprinting of prevascularized spheroids in photo-crosslinkable gelatin.

Biofabrication

De Moor L,Smet J,Plovyt M,Bekaert B,Vercruysse C,Asadian M,De Geyter N,Van Vlierberghe S,Dubruel P,Declercq H

Tue Sep 21 00:00:00 UTC 2021

Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.

Amino acids

Zhou Z,Liu XQ,Zhang SQ,Qi XM,Zhang Q,Yard B,Wu YG

Sat May 01 00:00:00 UTC 2021

Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).

Annals of translational medicine

Liu J,Li X,Lu S,Zheng X,Zhang X,Zhao W

Mon Mar 01 00:00:00 UTC 2021

Patterned vascularization in a directional ice-templated scaffold of decellularized matrix.

Engineering in life sciences

Shen L,Song X,Xu Y,Tian R,Wang Y,Li P,Li J,Bai H,Zhu H,Wang D

Fri Oct 01 00:00:00 UTC 2021

PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1^ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling.

Frontiers in pharmacology

Wang D,Zhao T,Zhao Y,Yin Y,Huang Y,Cheng Z,Wang B,Liu S,Pan M,Sun D,Wang Z,Zhu G

Tue Jun 22 00:00:00 UTC 2021

Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.

Clinical and experimental pharmacology & physiology

Zhao B,Li S,Guo Z,Chen Z,Zhang X,Xu C,Chen J,Wei C

Mon Mar 01 00:00:00 UTC 2021

Generation of Self-assembled Vascularized Human Skin Equivalents.

Journal of visualized experiments : JoVE

Sanchez MM,Morgan JT

Fri Feb 12 00:00:00 UTC 2021

FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.

Translational stroke research

Wang Z,Higashikawa K,Yasui H,Kuge Y,Ohno Y,Kihara A,Midori YA,Houkin K,Kawabori M

Thu Oct 01 00:00:00 UTC 2020

Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.

Diabetes, metabolic syndrome and obesity : targets and therapy

Ndibalema AR,Kabuye D,Wen S,Li L,Li X,Fan Q

Fri Apr 15 00:00:00 UTC 2022

circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis.

Biological & pharmaceutical bulletin

Wen S,Li S,Li L,Fan Q

Thu Sep 24 00:00:00 UTC 2020

USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.

Experimental cell research

Huang K,Zhao X

Sat Aug 15 00:00:00 UTC 2020

Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas.

Clinical and experimental nephrology

Du J,Liang L,Liu S,Yang X,Cao S,Zhang H,Su H,Gong X,Chen Q,Kong X,Xu D

Sun Nov 01 00:00:00 UTC 2020

Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.

Archives of medical research

Fan Z,Qi X,Yang W,Xia L,Wu Y

Sat Aug 01 00:00:00 UTC 2020

Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.

ACS biomaterials science & engineering

Liu B,Zhang S,Wang W,Yun Z,Lv L,Chai M,Wu Z,Zhu Y,Ma J,Leng L

Mon Oct 12 00:00:00 UTC 2020

Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.

Oxidative medicine and cellular longevity

Zhang Y,Tao C,Xuan C,Jiang J,Cao W

Fri May 14 00:00:00 UTC 2021

Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy.

Drug design, development and therapy

Zheng ZC,Zhu W,Lei L,Liu XQ,Wu YG

Fri Aug 06 00:00:00 UTC 2021

Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy.

Drug design, development and therapy

Zheng ZC,Zhu W,Lei L,Liu XQ,Wu YG

Fri Aug 06 00:00:00 UTC 2021

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.

Phytotherapy research : PTR

Li G,Lin J,Peng Y,Qin K,Wen L,Zhao T,Feng Q

Mon Jun 01 00:00:00 UTC 2020

Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.

American journal of translational research

Wei J,Wang Y,Qi X,Fan Z,Wu Y

Mon Sep 28 00:00:00 UTC 2020

Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress.

The EMBO journal

Schwörer S,Berisa M,Violante S,Qin W,Zhu J,Hendrickson RC,Cross JR,Thompson CB

Wed Apr 15 00:00:00 UTC 2020

Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.

Oxidative medicine and cellular longevity

Li X,Zou Y,Xing J,Fu YY,Wang KY,Wan PZ,Zhai XY

Mon Sep 21 00:00:00 UTC 2020

Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.

Oxidative medicine and cellular longevity

Li X,Zou Y,Xing J,Fu YY,Wang KY,Wan PZ,Zhai XY

Mon Sep 21 00:00:00 UTC 2020

miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.

International journal of molecular medicine

Jiang ZH,Tang YZ,Song HN,Yang M,Li B,Ni CL

Wed Jan 01 00:00:00 UTC 2020

The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.

Journal of cellular physiology

Li L,Xu L,Wen S,Yang Y,Li X,Fan Q

Wed Jul 01 00:00:00 UTC 2020

SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.

Frontiers in endocrinology

Geng H,Guo M,Xu W,Zang X,Wu T,Teng F,Wang Y,Liu X,Wang X,Sun Q,Liang J

Thu May 27 00:00:00 UTC 2021

Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.

The Journal of pharmacy and pharmacology

Xu J,Xiang P,Liu L,Sun J,Ye S

Sat Aug 01 00:00:00 UTC 2020

Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.

Journal of pharmacological sciences

Tan Y,Li Y,Zhou F,Guo J,Wang T,Shi Y,Yang Y,Lu J,Pei G

Wed Jul 01 00:00:00 UTC 2020

Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway.

Oxidative medicine and cellular longevity

Luan Y,Cui K,Tang Z,Ruan Y,Liu K,Wang T,Chen Z,Wang S,Liu J

Tue Nov 10 00:00:00 UTC 2020

Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca²⁺/CAMK II/ERK/NF-κB signaling pathway.

Acta pharmacologica Sinica

Ding XW,Sun X,Shen XF,Lu Y,Wang JQ,Sun ZR,Miao CH,Chen JW

Tue Oct 01 00:00:00 UTC 2019

Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca²⁺/CAMK II/ERK/NF-κB signaling pathway.

Acta pharmacologica Sinica

Ding XW,Sun X,Shen XF,Lu Y,Wang JQ,Sun ZR,Miao CH,Chen JW

Tue Oct 01 00:00:00 UTC 2019

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.

Journal of cellular and molecular medicine

Shang J,Wang L,Zhang Y,Zhang S,Ning L,Zhao J,Cheng G,Liu D,Xiao J,Zhao Z

Wed May 01 00:00:00 UTC 2019

Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.

Diabetes, metabolic syndrome and obesity : targets and therapy

Ma TK,Xu L,Lu LX,Cao X,Li X,Li LL,Wang X,Fan QL

Mon Apr 11 00:00:00 UTC 2022

Transplantation of adipose-derived stem cells overexpressing inducible nitric oxide synthase ameliorates diabetes mellitus-induced erectile dysfunction in rats.

PeerJ

Zhang Y,Yang J,Zhuan L,Zang G,Wang T,Liu J

Sat Apr 09 00:00:00 UTC 2022

lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.

Molecular therapy. Nucleic acids

Ge Y,Wang J,Wu D,Zhou Y,Qiu S,Chen J,Zhu X,Xiang X,Li H,Zhang D

Fri Sep 06 00:00:00 UTC 2019

Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.

EBioMedicine

Wang T,Fu X,Jin T,Zhang L,Liu B,Wu Y,Xu F,Wang X,Ye K,Zhang W,Ye L

Mon Jul 01 00:00:00 UTC 2019

SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.

Angiogenesis

Sun JX,Chang TF,Li MH,Sun LJ,Yan XC,Yang ZY,Liu Y,Xu WQ,Lv Y,Su JB,Liang L,Han H,Dou GR,Wang YS

Wed Aug 01 00:00:00 UTC 2018

SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.

Angiogenesis

Sun JX,Chang TF,Li MH,Sun LJ,Yan XC,Yang ZY,Liu Y,Xu WQ,Lv Y,Su JB,Liang L,Han H,Dou GR,Wang YS

Wed Aug 01 00:00:00 UTC 2018

Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.

International journal of biological macromolecules

Sun D,Liu Y,Wang H,Deng F,Zhang Y,Zhao S,Ma X,Wu H,Sun G

Sun Apr 01 00:00:00 UTC 2018

Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.

International journal of biological macromolecules

Sun D,Liu Y,Wang H,Deng F,Zhang Y,Zhao S,Ma X,Wu H,Sun G

Sun Apr 01 00:00:00 UTC 2018

Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.

Experimental cell research

Liu L,Li Y,Wang Z,Ding F,Cheng Z,Xu Q,Cai Y,Limbu MH,Yang Y,Liu B,Chen P

Sat Sep 15 00:00:00 UTC 2018

Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.

Experimental cell research

Liu L,Li Y,Wang Z,Ding F,Cheng Z,Xu Q,Cai Y,Limbu MH,Yang Y,Liu B,Chen P

Sat Sep 15 00:00:00 UTC 2018

Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.

Experimental cell research

Liu L,Li Y,Wang Z,Ding F,Cheng Z,Xu Q,Cai Y,Limbu MH,Yang Y,Liu B,Chen P

Sat Sep 15 00:00:00 UTC 2018

5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.

Bioscience reports

Quesada A,O'Valle F,Montoro-Molina S,Gómez-Morales M,Caba-Molina M,González JF,de Gracia MC,Osuna A,Vargas F,Wangensteen R

Fri Apr 27 00:00:00 UTC 2018

5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.

Bioscience reports

Quesada A,O'Valle F,Montoro-Molina S,Gómez-Morales M,Caba-Molina M,González JF,de Gracia MC,Osuna A,Vargas F,Wangensteen R

Fri Apr 27 00:00:00 UTC 2018

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.

Cell death & disease

Li A,Peng R,Sun Y,Liu H,Peng H,Zhang Z

Tue May 01 00:00:00 UTC 2018

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.

Cell death & disease

Li A,Peng R,Sun Y,Liu H,Peng H,Zhang Z

Tue May 01 00:00:00 UTC 2018

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.

Cell death & disease

Li A,Peng R,Sun Y,Liu H,Peng H,Zhang Z

Tue May 01 00:00:00 UTC 2018

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.

Cell death & disease

Li A,Peng R,Sun Y,Liu H,Peng H,Zhang Z

Tue May 01 00:00:00 UTC 2018

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.

Molecular therapy. Nucleic acids

Li XY,Wang SS,Han Z,Han F,Chang YP,Yang Y,Xue M,Sun B,Chen LM

Fri Dec 15 00:00:00 UTC 2017

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.

Molecular therapy. Nucleic acids

Li XY,Wang SS,Han Z,Han F,Chang YP,Yang Y,Xue M,Sun B,Chen LM

Fri Dec 15 00:00:00 UTC 2017

CAPE-pNO₂ ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.

Oncotarget

Wang X,Li D,Fan L,Xiao Q,Zuo H,Li Z

Fri Dec 29 00:00:00 UTC 2017

CAPE-pNO₂ ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.

Oncotarget

Wang X,Li D,Fan L,Xiao Q,Zuo H,Li Z

Fri Dec 29 00:00:00 UTC 2017

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.

Cell death & disease

Yi H,Peng R,Zhang LY,Sun Y,Peng HM,Liu HD,Yu LJ,Li AL,Zhang YJ,Jiang WH,Zhang Z

Thu Feb 02 00:00:00 UTC 2017

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.

Cell death & disease

Yi H,Peng R,Zhang LY,Sun Y,Peng HM,Liu HD,Yu LJ,Li AL,Zhang YJ,Jiang WH,Zhang Z

Thu Feb 02 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: arresten; COL4A1 NC1 domain; Collagen 4; Collagen alpha-1(IV) chain; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen, type IV, alpha 1; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; dA149D17.3; dA24A23.1; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; tumstatin; Type IV Collagen

View more View less

Gene Aliases: ASLN; ATS; BSVD; CA44; CA54; COL4A1; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; DELXq22.3; DFNX6; ICH; POREN2; RATOR

View more View less

UniProt ID: (Human) P02462, (Human) P08572, (Human) Q01955, (Human) P53420, (Human) P29400, (Human) Q14031

View more View less

Entrez Gene ID: (Human) 1282, (Human) 1284, (Human) 1285, (Human) 1286, (Human) 1287, (Human) 1288

View more View less

extracellular matrix structural constituent protein binding extracellular matrix constituent conferring elasticity platelet-derived growth factor binding integrin binding structural molecule activity metalloendopeptidase inhibitor activity

extracellular matrix organization collagen catabolic process glomerular basement membrane development activation of cysteine-type endopeptidase activity involved in apoptotic process cell adhesion cell surface receptor signaling pathway sensory perception of sound blood circulation cell proliferation negative regulation of cell proliferation negative regulation of endopeptidase activity negative regulation of angiogenesis endothelial cell apoptotic process patterning of blood vessels brain development neuromuscular junction development epithelial cell differentiation blood vessel morphogenesis retinal blood vessel morphogenesis renal tubule morphogenesis cellular response to amino acid stimulus basement membrane organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support