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  • Chromogranin A Antibodies

NeoBiotechnologies

Chromogranin A/CHGA (Neuroendocrine Marker) Monoclonal Antibody (CGA/413, CHGA/777, CHGA/798)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite Chromogranin A/CHGA (Neuroendocrine Marker) Monoclonal Antibody (CGA/413, CHGA/777, CHGA/798)

  • Antibody Testing Data (4)
Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Chromogranin A/CHGA (Neuroendocrine Marker) Antibody (1113-MSM10-P0) in IHC (P)

Formalin-fixed, paraffin-embedded Pheochromocytoma stained with Chromogranin A Monoclonal Antibody (CGA/413+CHGA/777+CHGA/798). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Chromogranin A/CHGA (Neuroendocrine Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Details

1113-MSM10-P0

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

0.25-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

CGA/413, CHGA/777, CHGA/798

Immunogen

Recombinant human chromogranin A protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Wet ice

Target Information

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; pancreastatin; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I

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Gene Aliases: CGA; CHGA; ChrA

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UniProt ID: (Pig) P04404, (Human) P10645, (Mouse) P26339

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Entrez Gene ID: (Pig) 397540, (Human) 1113, (Rat) 24258, (Mouse) 12652

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Function(s)
protein binding
Process(es)
regulation of the force of heart contraction organelle organization positive regulation of cAMP metabolic process ovulation cycle negative regulation of vasodilation positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of neuron death mast cell chemotaxis regulation of blood pressure killing of cells of other organism mast cell cytokine production negative regulation of catecholamine secretion mast cell degranulation innate immune response mast cell activation defense response to Gram-negative bacterium defense response to Gram-positive bacterium defense response to fungus positive regulation of cardiac muscle contraction adrenergic receptor signaling pathway involved in cardiac muscle relaxation positive regulation of relaxation of cardiac muscle positive regulation of dense core granule biogenesis
It has to be done as per old AB suggested Products section.
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