Proteintech

Calpain 3 Polyclonal Antibody

View all (11) Calpain 3 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Calpain 3 Polyclonal Antibody

Product Details

10415-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Calpain 3 Fusion Protein Ag0671 (1-156 aa encoded by BC003521)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEICADELK KVLNTVVNKH KDLKTHGFTL ESCRSMIALM DTDGSGKLNL QEFHHLWNKI KAWQKIFKHY DTDQSGTINS YEMRNAVNDA GFHLNNQLYD IITMRYADKH MNIDFDSFIC CFVRLEGMFR AFHAFDKDGD GIIKLNVLEW LQLTMYA (1-156 aa encoded by BC003521)

Target Information

Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CANP 3; CAPN 3; LGMD 2A; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; skeletal muscle specific calpain p94

View more View less

Gene Aliases: AI323605; CANP3; CANPL3; Capa-3; Capa3; CAPN3; LGMD2; LGMD2A; Lp82; Lp84; Lp85; nCL-1; NCL1; p94

View more View less

UniProt ID: (Human) P20807, (Mouse) Q64691, (Rat) P16259

View more View less

Entrez Gene ID: (Human) 825, (Mouse) 12335, (Rat) 29155

View more View less

Function(s)
catalytic activity calcium-dependent cysteine-type endopeptidase activity signal transducer activity calcium ion binding protein binding peptidase activity cysteine-type peptidase activity structural constituent of muscle sodium ion binding titin binding protein complex scaffold ligase regulator activity receptor binding hydrolase activity enzyme binding metal ion binding
Process(es)
autolysis protein complex assembly proteolysis positive regulation of satellite cell activation involved in skeletal muscle regeneration response to muscle activity myofibril assembly negative regulation of protein sumoylation negative regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling sarcomere organization regulation of myoblast differentiation positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of catalytic activity positive regulation of NF-kappaB transcription factor activity positive regulation of release of sequestered calcium ion into cytosol response to calcium ion muscle structure development G1 to G0 transition involved in cell differentiation cellular response to calcium ion cellular response to salt stress protein localization to membrane self proteolysis sodium-dependent self proteolysis response to drug apoptotic process signal transduction muscle organ development muscle cell cellular homeostasis negative regulation of skeletal muscle cell differentiation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support