Invitrogen

CaMKII delta Monoclonal Antibody (GT4811)

1 Reference
View all (18) CaMKII delta antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-27735

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rabbit

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

GT4811

Immunogen

Recombinant protein encompassing a sequence within the center region of human CaMKII. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735137

Product Specific Information

Positive Control: U87-MG, SK-N-SH, Neuro 2A, C8D30, NIH-3T3, mouse brain, rat brain, transfected 293T

Predicted Reactivity: Xenopus laevis (94%), Pig (100%), Rabbit (99%), Chicken (98%), Bovine (99%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CaMKII delta belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CAM2; CaMK-II delta subunit; caMK-II subunit delta; CAMK2B; CAMK2G; CAMKB; CAMKG

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Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CaMK II; CAMK1; Camk2; CAMK2D; CAMKD; Camki; Kiaa4163; RATCAMKI

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UniProt ID: (Human) Q13557, (Rat) P15791, (Mouse) Q6PHZ2

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Entrez Gene ID: (Human) 817, (Rat) 24246, (Mouse) 108058

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Function(s)
protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding sodium channel inhibitor activity titin binding protein homodimerization activity ion channel binding nitric-oxide synthase binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
G1/S transition of mitotic cell cycle MAPK cascade regulation of cell growth response to hypoxia regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport regulation of heart contraction regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of GTPase activity protein autophosphorylation positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity interferon-gamma-mediated signaling pathway regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cellular response to heat regulation of histone deacetylase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity regulation of sodium ion transport cardiac muscle contraction phosphorylation
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