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OriGene
CYP2B6 Monoclonal Antibody (OTI3D5), TrueMAB™
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Product Details
CF504328
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
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Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 1,4-cineole 2-exo-monooxygenase; CYPIIB11; CYPIIB3; CYPIIB6; Cytochrome P450 2B11; Cytochrome P450 2B3; Cytochrome P450 2B6; Cytochrome P450 IIB1; Cytochrome P450 PBD-2; cytochrome P450, family 2, subfamily B, polypeptide 11; cytochrome P450, family 2, subfamily B, polypeptide 6; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450IIB3; Cytochrome-P450-2B11
Gene Aliases: CPB6; CYP2B; Cyp2b-3; CYP2B11; Cyp2b3; CYP2B6; CYP2B7; CYP2B7P; CYPIIB11; CYPIIB6; EFVM; IIB1; P450
UniProt ID: (Human) P20813, (Dog) P24460, (Rat) P13107
Entrez Gene ID: (Human) 1555, (Dog) 474177, (Rat) 286953
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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