Invitrogen

CYP1B1 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
CYP1B1 Polyclonal Antibody

Product Details

PA5-106878

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CYP1B1(Accession Q16678), corresponding to amino acid residues M205-R255.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854542

Product Specific Information

Antibody detects endogenous levels of total CYP1B1.

Target Information

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CYPIB1; Cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); Cytochrome P450CMEF; Cytochrome P450EF; Cytochrome P450RAP; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P450RAP; xenobiotic monooxygenase

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Gene Aliases: CP1B; Cyp1-b1; CYP1B1; CYPIB1; GLC3A; P4501B1

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UniProt ID: (Human) Q16678, (Rat) Q64678, (Mouse) Q64429

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Entrez Gene ID: (Human) 1545, (Rat) 25426, (Mouse) 13078

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Function(s)
monooxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding
Process(es)
angiogenesis trabecular meshwork development DNA modification cellular aromatic compound metabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion response to nutrient steroid metabolic process estrogen metabolic process negative regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance response to organic substance positive regulation of vascular endothelial growth factor production response to organic cyclic compound positive regulation of smooth muscle cell migration dibenzo-p-dioxin metabolic process arachidonic acid metabolic process collagen fibril organization adrenal gland development negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity response to follicle-stimulating hormone response to estradiol negative regulation of cell adhesion mediated by integrin benzene-containing compound metabolic process retinol metabolic process retinal metabolic process positive regulation of apoptotic process endothelial cell migration estrous cycle positive regulation of translation positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process response to arsenic-containing substance blood vessel morphogenesis response to steroid hormone oxidation-reduction process retina vasculature development in camera-type eye retinal blood vessel morphogenesis ganglion development cellular response to hydrogen peroxide cellular response to cAMP cellular response to tumor necrosis factor cellular response to luteinizing hormone stimulus cellular response to cortisol stimulus cellular response to progesterone stimulus cellular response to organic cyclic compound response to dexamethasone endothelial cell-cell adhesion response to indole-3-methanol regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process visual perception sterol metabolic process epoxygenase P450 pathway omega-hydroxylase P450 pathway
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