Invitrogen

CYBA Monoclonal Antibody (CS9)

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Datasheet
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Datasheet
Protocols
Questions & Answers
CYBA Monoclonal Antibody (CS9)

Product Details

MA5-18047

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CS9

Immunogen

Partially purified human neutrophil flavocytochrome b (heparin Ultrogellectin affinity purification in octyl glucoside)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539430

Product Specific Information

This antibody is specific for human Cytochrome b245 light chain (aa 165-169, KKPSE).

This target has a predicted molecular weight of 21 kDa.

Target Information

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit

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Gene Aliases: CYBA; p22-PHOX

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UniProt ID: (Human) P13498

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Entrez Gene ID: (Human) 1535

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Function(s)
protein binding electron carrier activity superoxide-generating NADPH oxidase activity SH3 domain binding heme binding metal ion binding protein heterodimerization activity
Process(es)
response to reactive oxygen species positive regulation of endothelial cell proliferation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent negative regulation of glomerular filtration by angiotensin superoxide metabolic process inflammatory response smooth muscle hypertrophy cytochrome complex assembly positive regulation of cell growth response to nutrient levels positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway response to drug superoxide anion generation innate immune response cell redox homeostasis respiratory burst vascular endothelial growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation hydrogen peroxide biosynthetic process positive regulation of phagocytosis regulation of release of sequestered calcium ion into cytosol oxidation-reduction process positive regulation of mucus secretion response to interleukin-1 cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound cellular response to gamma radiation positive regulation of defense response to bacterium positive regulation of reactive oxygen species biosynthetic process
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