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  • Primary Antibodies ›
  • CXCR2 Antibodies

Invitrogen

CXCR2 Monoclonal Antibody (48311.211)

View all (37) CXCR2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite CXCR2 Monoclonal Antibody (48311.211)

Product Details

MA1-24669

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µg for 10^5 PBMC
-

Neutralization (Neu)

Assay-dependent
-

Inhibition Assays (IA)

0.5-1.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

48311.211

Immunogen

Human CXCR2 transfected NSO mouse myeloma cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779601

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B

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Gene Aliases: CD182; CDw128b; CMKAR2; CXCR2; IL8R2; IL8RA; IL8RB

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UniProt ID: (Human) P25025

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Entrez Gene ID: (Human) 3579

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Function(s)
signal transducer activity interleukin-8 receptor activity protein binding C-X-C chemokine receptor activity interleukin-8 binding
Process(es)
dendritic cell chemotaxis chemotaxis inflammatory response cellular defense response signal transduction cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cell proliferation neutrophil chemotaxis receptor internalization interleukin-8-mediated signaling pathway neutrophil activation chemokine-mediated signaling pathway
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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