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Invitrogen
CX3CL1 Polyclonal Antibody
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Product Details
PA1-29026
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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Purification
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Product Specific Information
Recommended positive controls: CX3CL1 detected in rat and mouse brain.
Target Information
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABCD-3; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1
Gene Aliases: AB030188; ABCD-3; Acc1; AI848747; CX3C; Cx3cl1; Cxc3; D8Bwg0439e; Fkn; Scyd1
UniProt ID: (Rat) O55145, (Mouse) O35188
Entrez Gene ID: (Rat) 89808, (Mouse) 20312
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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