Invitrogen

CTGF Polyclonal Antibody

1 Published Figure
1 Reference
View all (43) CTGF antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
CTGF Polyclonal Antibody

Product Details

PA1-22376

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment, corresponding to amino acids 223-348 of Mouse CTGF.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2230148

Product Specific Information

PA1-22376 detects CTGF in Human, Mouse and Rat samples.

Target Information

Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); Connective tissue growth-related protein; fibroblast inducible secreated protein; fibroblast inducible secreted protein; H-CTGF; hypertrophic chondrocyte-specific gene product 24; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839; Protein FISP-12

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Gene Aliases: betaIG-M2; CCN2; CTGF; CTGRP; Fisp-12; Fisp12; HCS24; IGFBP8; NOV2

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UniProt ID: (Human) P29279, (Mouse) P29268, (Rat) Q9R1E9

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Entrez Gene ID: (Human) 1490, (Mouse) 14219, (Rat) 64032

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Function(s)
fibronectin binding integrin binding protein binding insulin-like growth factor binding protein C-terminus binding growth factor activity heparin binding
Process(es)
cartilage condensation ossification angiogenesis regulation of cell growth tissue homeostasis positive regulation of protein phosphorylation cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of gene expression negative regulation of gene expression positive regulation of cell death cell migration cell differentiation lung development regulation of chondrocyte differentiation positive regulation of collagen biosynthetic process intracellular signal transduction chondrocyte proliferation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell differentiation positive regulation of JNK cascade positive regulation of cell activation positive regulation of stress fiber assembly cytosolic calcium ion transport positive regulation of cardiac muscle contraction negative regulation of cell death connective tissue development extracellular matrix constituent secretion positive regulation of G0 to G1 transition positive regulation of ERK1 and ERK2 cascade DNA biosynthetic process reactive oxygen species metabolic process transcription initiation from RNA polymerase II promoter epidermis development response to wounding response to glucose organ senescence response to estradiol response to anoxia response to amino acid response to peptide hormone response to mineralocorticoid response to fatty acid response to organic cyclic compound
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