Alomone Labs, LTD

CRF1/CRHR1 (extracellular) Polyclonal Antibody, FITC

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Datasheet
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Datasheet
Protocols
Questions & Answers
CRF1/CRHR1 (extracellular) Polyclonal Antibody, FITC

Product Details

ACR-050-F-50UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ENLSLTSNVSGLQC, corresponding to amino acid residues 31-44 of rat CRHR1, Extracellular, N-terminus
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Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; Corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF 1 receptor; Crf receptor 1; Crf type 1; CRF-R; CRF-R-1; CRF-R1; CRF-R1alpha; CRF1; Crf1 receptor; CRFR-1; CRH receptor 1; CRH receptor subtype-1 isoform-3; CRH-R 1; CRH-R-1; CRH-R1; CRH-R1h; CRHR1f; seven transmembrane helix receptor

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Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1; CRHR1L

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UniProt ID: (Human) P34998, (Rat) P35353, (Mouse) P35347

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Entrez Gene ID: (Human) 1394, (Rat) 58959, (Mouse) 12921

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Function(s)
protein binding corticotrophin-releasing factor receptor activity G-protein alpha-subunit binding G-protein coupled receptor activity protein complex binding peptide binding corticotropin-releasing hormone receptor activity corticotropin-releasing hormone binding signal transducer activity transmembrane signaling receptor activity
Process(es)
response to hypoxia G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway memory feeding behavior visual learning hormone-mediated signaling pathway regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway hypothalamus development adrenal gland development positive regulation of cAMP biosynthetic process epithelial cell differentiation negative regulation of epinephrine secretion locomotory exploration behavior response to immobilization stress fear response positive regulation of mast cell degranulation behavioral response to cocaine behavioral response to ethanol regulation of synaptic plasticity behavioral response to pain corticotropin secretion response to electrical stimulus general adaptation syndrome, behavioral process long-term synaptic potentiation cellular response to corticotropin-releasing hormone stimulus negative regulation of neuron death negative regulation of voltage-gated calcium channel activity negative regulation of feeding behavior regulation of corticosterone secretion immune response cell surface receptor signaling pathway activation of adenylate cyclase activity female pregnancy parturition signal transduction
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