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Invitrogen
CRALBP Monoclonal Antibody (B2)
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Product Details
MA1-813
Species Reactivity
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Conjugate
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Product Specific Information
MA1-813 detects CRALBP protein in bovine, human, mouse, non-human primate and rat samples.
MA1-813 has successfully been used in Western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence procedures. By Western blot, this antibody detects a 37 kDa protein representing human recombinant CRALBP.
The MA1-813 immunogen is purified human recombinant CRALBP.
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; Retinaldehyde-binding protein 1
Gene Aliases: 3110056M11Rik; BOS_20120; CRALBP; RLBP1
UniProt ID: (Human) P12271, (Bovine) P10123, (Mouse) Q9Z275
Entrez Gene ID: (Human) 6017, (Bovine) 282038, (Mouse) 19771, (Rat) 293049
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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