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Invitrogen
COPS7A Polyclonal Antibody
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FIGURE: 1 / 5
COPS7A Antibody (PA5-103079) in ICC/IF
Product Details
PA5-103079
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Antibody detects endogenous levels of total COPS7A.
Target Information
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 complex subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A; COP9 signalosome complex subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; SGN7a; signalosome subunit 7a
Gene Aliases: COPS7A; CSN7; CSN7A; D6Ertd35e; DERP10; SGN7a
UniProt ID: (Human) Q9UBW8, (Mouse) Q9CZ04
Entrez Gene ID: (Human) 50813, (Rat) 312710, (Mouse) 26894
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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