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OriGene
CNOT4 Monoclonal Antibody (OTI3D11), TrueMAB™
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Product Details
TA504447
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Target Information
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; E3 ubiquitin-protein ligase CNOT4; NOT4 (negative regulator of transcription 4, yeast) homolog; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4
Gene Aliases: CLONE243; CNOT4; NOT4; NOT4H
UniProt ID: (Human) O95628
Entrez Gene ID: (Human) 4850
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