Invitrogen

CLOCK Recombinant Rabbit Monoclonal Antibody (3D8H6)

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Datasheet
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Datasheet
Protocols
Questions & Answers
CLOCK Recombinant Rabbit Monoclonal Antibody (3D8H6)

Product Details

MA5-38168

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3D8H6

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CLOCK (NP_0048891)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898085

Product Specific Information

Positive Samples: HeLa, 293T, NIH/3T3, SH-SY5Y, Mouse lung, Rat brain

Immunogen sequence: WKPTFLSNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR G

Target Information

This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHe8; circadian locomoter output cycles kaput; circadian locomoter output cycles kaput protein; Circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock homolog; hCLOCK; mCLOCK; rCLOCK

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Gene Aliases: 5330400M04Rik; BHLHE8; CLOCK; KAT13D; KIAA0334

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UniProt ID: (Human) O15516, (Mouse) O08785, (Rat) Q9WVS9

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Entrez Gene ID: (Human) 9575, (Mouse) 12753, (Rat) 60447

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity protein binding chromatin DNA binding sequence-specific DNA binding protein dimerization activity E-box binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding signal transducer activity transcription factor binding transferase activity transferase activity, transferring acyl groups
Process(es)
DNA damage checkpoint transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to DNA damage stimulus signal transduction spermatogenesis circadian rhythm histone acetylation circadian regulation of gene expression regulation of hair cycle proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state cellular response to ionizing radiation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of transcription from RNA polymerase II promoter photoperiodism entrainment of circadian clock
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