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Invitrogen
CLIC5 Monoclonal Antibody (CLIC5-02)
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Product Details
MA5-28624
Species Reactivity
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Conjugate
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Product Specific Information
This antibody recognizes CLIC5a, a 32 kDa intracellular protein which associates with proteins of actin complexes. Cross reactivity with CLIC5b was not determined.
Target Information
Clic5 encodes a protein that is required for normal hearing and is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Clic5 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Clic5 may play a role in the regulation of transepithelial ion absorption and secretion, and is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. The Clic5 gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The protein encoded by Clic5 associates with actin-based cytoskeletal structures and may also play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the Clic5 gene. Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Chloride intracellular channel protein 5; Glutaredoxin-like oxidoreductase CLIC5
Gene Aliases: CLIC5; DFNB102; DFNB103; MST130; MSTP130
UniProt ID: (Human) Q9NZA1
Entrez Gene ID: (Human) 53405
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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