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  • Primary Antibodies ›
  • CHP1 Antibodies

Invitrogen

CHP1 Polyclonal Antibody

View all (21) CHP1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite CHP1 Polyclonal Antibody

  • Antibody Testing Data (3)
CHP1 Antibody in Immunocytochemistry (ICC/IF)
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CHP1 Antibody in Immunocytochemistry (ICC/IF)
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CHP1 Antibody (PA5-22189) in ICC/IF

Immunocytochemistry analysis of CHP1 in methanol-fixed HepG2. Samples were incubated with CHP1 polyclonal antibody (Product # PA5-22189) using a dilution of 1:200. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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CHP1 Antibody in Immunocytochemistry (ICC/IF)
CHP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
CHP1 Antibody in Western Blot (WB)

Product Details

PA5-22189

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Calcium binding protein p22. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11155791

Product Specific Information

Recommended positive controls: HepG2.

Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calcineurin B homolog; Calcineurin B homologous protein 1; Calcineurin B-like protein; calcineurin homologous protein; calcineurin-like EF hand protein 1; calcineurin-like EF-hand protein 1; calcium binding protein P22; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22; SLC9A1 binding protein

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Gene Aliases: CHP; CHP1; p22; p24; Sid470p; SLC9A1BP

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UniProt ID: (Human) Q99653

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Entrez Gene ID: (Human) 11261

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Function(s)
protein kinase inhibitor activity transporter activity calcium ion binding protein binding microtubule binding potassium channel regulator activity kinase binding calcium-dependent protein binding
Process(es)
microtubule bundle formation negative regulation of protein phosphorylation negative regulation of protein kinase activity protein export from nucleus potassium ion transport small GTPase mediated signal transduction negative regulation of phosphatase activity calcium ion regulated exocytosis membrane docking hyaluronan catabolic process cytoplasmic microtubule organization negative regulation of protein ubiquitination negative regulation of protein autophosphorylation negative regulation of NF-kappaB transcription factor activity positive regulation of sodium:proton antiporter activity negative regulation of protein import into nucleus protein stabilization positive regulation of protein transport protein oligomerization regulation of intracellular pH positive regulation of protein glycosylation membrane organization membrane fusion negative regulation of calcineurin-NFAT signaling cascade cellular response to acidic pH positive regulation of protein targeting to membrane regulation of neuron death
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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