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Invitrogen
CENPB Monoclonal Antibody (A5F6)
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FIGURE: 1 / 4
CENPB Antibody (MA5-42559) in ICC/IF
Product Details
MA5-42559
Species Reactivity
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Conjugate
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Product Specific Information
Positive Control: Hela cell lysate, A549 cell lysate, MCF-7 cell lysate, SH-SY5Y, human kidney tissue, human skin tissue.
Subcellular Location: Nucleus, centromere.
Target Information
CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CENP-B; centromere autoantigen B; Centromere protein B; centromere protein B, 80kDa; Major centromere autoantigen B
Gene Aliases: CENPB
UniProt ID: (Human) P07199
Entrez Gene ID: (Human) 1059
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