Invitrogen

CEACAM1/CEACAM3/CEACAM6 Monoclonal Antibody (YTH71.3)

View all (2) CEACAM1/CEACAM3/CEACAM6 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
CEACAM1/CEACAM3/CEACAM6 Monoclonal Antibody (YTH71.3)

Product Details

MA1-90031

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Flow Cytometry (Flow)

10 µL for 10^6 cells in 100 µL
-
Product Specifications

Species Reactivity

Human, Rhesus monkey

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

YTH71.3

Immunogen

Human lymphocytes.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2260310

Product Specific Information

MA1-90031 detects CD66a, CD66c + CD66d from non-human primate, human samples.

Target Information

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen CGM1; carcinoembryonic antigen gene family member 1; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 3; carcinoembryonic antigen-related cell adhesion molecule 5-like; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66a antigen; CD66c; CD66d; CD66d antigen; CEA cell adhesion molecule 1; CEA cell adhesion molecule 3; CEA cell adhesion molecule 6; Cell adhesion molecule CEACAM1; Cell adhesion molecule CEACAM3; Cell adhesion molecule CEACAM6; Cluster of Differentiation 66c; Non-specific crossreacting antigen; nonspecific cross-reacting antigen; Normal cross-reacting antigen; pan CEACAM

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Gene Aliases: BGP; BGP1; BGPI; CD66c; CD66D; CEA; CEACAM1; CEACAM3; CEACAM6; CEAL; CGM1; NCA; W264; W282

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UniProt ID: (Human) P13688, (Human) P40198, (Human) P40199

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Entrez Gene ID: (Human) 634, (Human) 1084, (Human) 4680, (Rhesus monkey) 707824

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Function(s)
molecular_function actin binding protein binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding
Process(es)
angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules integrin-mediated signaling pathway regulation of endothelial cell migration regulation of phosphatidylinositol 3-kinase signaling bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway leukocyte migration negative regulation of lipid biosynthetic process regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis signal transduction cell-cell signaling
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