Invitrogen

CEACAM1 Monoclonal Antibody (C4)

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Datasheet
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Datasheet
Protocols
Questions & Answers
CEACAM1 Monoclonal Antibody (C4)

Product Details

MA5-50869

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-
Product Specifications

Species Reactivity

Horse, Guinea pig, Human, Sheep, Pig, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

C4

Immunogen

Recombinant Human CEACAM1 protein, Gln35-Leu321 (Accession P13688).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093404

Target Information

CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD66; ATP-dependent taurocolate-carrier protein; BGP-1; Biliary glycoprotein 1; bone gamma-carboxyglutamic acid (Gla) protein; C-CAM 105; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a; CD66a antigen; CEA cell adhesion molecule 1; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); Cell adhesion molecule CEACAM1; Cell-CAM 105; Ecto-ATPase; GP110; osteocalcin; pp120; pp120/ecto-ATPase

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Gene Aliases: BGP; BGP1; BGPI; BGPR; Ccam1; CD66a; CEACAM1

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UniProt ID: (Human) P13688, (Rat) P16573

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Entrez Gene ID: (Human) 634, (Rat) 81613

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Function(s)
molecular_function actin binding protein binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding virus receptor activity protein kinase binding virion binding
Process(es)
angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules integrin-mediated signaling pathway regulation of endothelial cell migration regulation of phosphatidylinositol 3-kinase signaling bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway leukocyte migration negative regulation of lipid biosynthetic process regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis negative regulation of cytokine production signal transduction calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules negative regulation of interleukin-2 production positive regulation of T cell proliferation negative regulation of T cell proliferation positive regulation of MAP kinase activity negative regulation by host of viral process positive regulation by host of viral process negative regulation by host of viral genome replication negative regulation of JNK cascade positive regulation of JNK cascade viral entry into host cell Peyer's patch development positive regulation of immunoglobulin secretion positive regulation of NFAT protein import into nucleus protein homotrimerization positive regulation of activation-induced cell death of T cells positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation
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