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Proteintech
CD72 Polyclonal Antibody
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Product Details
13469-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: VRYLQVSQQ LQQTNRVLEV TNSSLRQQLR LKITQLGQSA EDLQGSRREL AQSQEALQVE QRAHQAAEGQ LQACQADRQK TKETLQSEEQ QRRALEQKLS NMENRLKPFF TCGSADTCCP SGWIMHQKSC FYISLTSKNW QESQKQCETL SSKLATFSEI YPQSHSYYFL NSLLPNGGSG NSYWTGLSSN KDWKLTDDTQ RTRTYAQSSK CNKVHKTWSW WTLESESCRS SLPYICEMTA FRFPD (116-359 aa encoded by BC030227)
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: B-cell differentiation antigen CD72; CD72; CD72 antigen; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
Gene Aliases: CD72; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2; LYB2
UniProt ID: (Human) P21854, (Mouse) P21855
Entrez Gene ID: (Human) 971, (Mouse) 12517
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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