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NeoBiotechnologies
CD31/PECAM-1 (Endothelial Cell Marker) Monoclonal Antibody (C31.7)
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Product Details
5175-MSM1-P1ABX
Species Reactivity
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Clone
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Conjugate
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Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD31; CD31 antigen; EndoCAM; Fc receptor-like 4-like; GPIIA'; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
Gene Aliases: CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; Pecam; PECAM-1; PECAM1
UniProt ID: (Human) P16284, (Rat) Q3SWT0
Entrez Gene ID: (Rabbit) 100357605, (Cynomolgus monkey) 102117792, (Human) 5175, (Rat) 29583
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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