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Invitrogen
CD13 Polyclonal Antibody
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Product Details
PA5-82156
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: PNTLKPDSYR VTLRPYLTPN DRGLYVFKGS STVRFTCKEA TDVIIIHSKK LNYTLSQGHR VVLRGVGGSQ PPDIDKTELV EPTEYLVVHL KGSLVKDSQY EMDSEFEGEL ADDLAGFYRS EYMEGNVRKV VATTQMQA
Target Information
CD13, also known as ANPEP, is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on a wide variety of cell types and tissues. It is prominently found on monocytes and granulocytes in the blood, but not on lymphocytes. Additionally, CD13 is expressed on endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, placenta, and myeloid leukemia cells. As a metalloprotease, CD13 preferentially catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides. It plays a crucial role in various biological processes, including the degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and the adhesion and migration of cells. CD13 is also involved in extracellular matrix degradation, signal transduction, inflammatory responses, regulation of intercellular contact, cell motility, and vascularization. In the context of disease, CD13 is associated with the protection of leukemic cells against apoptosis and is linked to a poor prognosis in carcinomas. Furthermore, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; AP-M; AP-N; CD13; gp150; h AP-N; hAPN; membrane alanyl aminopeptidase; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13
Gene Aliases: ANPEP; APN; CD13; GP150; LAP1; P150; PEPN
UniProt ID: (Human) P15144
Entrez Gene ID: (Human) 290
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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