Proteintech

CCR7 Polyclonal Antibody

13 References
View all (59) CCR7 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
CCR7 Polyclonal Antibody

Product Details

25898-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

-
View 4 publications 4 publications
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCR7 Fusion Protein Ag22941 (279-378 aa encoded by BC035343)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YNGVVLAQT VANFNITSST CELSKQLNIA YDVTYSLACV RCCVNPFLYA FIGVKFRNDL FKLFKDLGCL SQEQLRQWSS CRHIRRSSMS VEAETTTTFS P (279-378 aa encoded by BC035343)

Target Information

CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; CC chemokine receptor 7; CD197; CDw197; chemokine (C-C motif) receptor 7; EBI1; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

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Gene Aliases: BLR2; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; CMKBR7; EBI1; EVI1

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UniProt ID: (Human) P32248

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Entrez Gene ID: (Human) 1236, (Rat) 287673

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Function(s)
G-protein coupled receptor activity C-C chemokine receptor activity chemokine (C-C motif) ligand 19 binding chemokine (C-C motif) ligand 21 binding C-C motif chemokine 19 receptor activity C-C motif chemokine 21 receptor activity
Process(es)
myeloid dendritic cell chemotaxis positive regulation of dendritic cell antigen processing and presentation positive regulation of hypersensitivity positive regulation of humoral immune response chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway response to lipopolysaccharide regulation of interferon-gamma production positive regulation of interleukin-12 production chemokine (C-C motif) ligand 19 signaling pathway chemokine (C-C motif) ligand 21 signaling pathway negative thymic T cell selection regulation of interleukin-1 beta secretion positive regulation of T cell receptor signaling pathway chemokine-mediated signaling pathway cellular response to cytokine stimulus interleukin-12 secretion positive regulation of neutrophil chemotaxis mature conventional dendritic cell differentiation positive regulation of dendritic cell chemotaxis positive regulation of immunological synapse formation positive regulation of T cell costimulation positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation establishment of T cell polarity positive regulation of cell-matrix adhesion dendritic cell chemotaxis positive regulation of cytosolic calcium ion concentration positive regulation of actin filament polymerization positive regulation of pseudopodium assembly ruffle organization response to prostaglandin E positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cell adhesion positive regulation of protein kinase activity positive regulation of JNK cascade homeostasis of number of cells release of sequestered calcium ion into cytosol positive regulation of filopodium assembly positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade response to nitric oxide activation of GTPase activity lymphocyte migration into lymph node negative regulation of leukocyte apoptotic process positive regulation of cell motility regulation of dendritic cell dendrite assembly
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