Fabgennix

CCR5 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
CCR5 Polyclonal Antibody

Product Details

CCR5-501AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; chemokine receptor CCR5; CHEMR13; HIV-1 fusion coreceptor; MIP-1 alpha receptor

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Gene Aliases: CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22

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UniProt ID: (Human) P51681, (Rat) O08556

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Entrez Gene ID: (Human) 1234, (Rat) 117029

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Function(s)
virus receptor activity actin binding phosphatidylinositol phospholipase C activity chemokine receptor activity protein binding coreceptor activity C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 5 binding glycoprotein binding protein kinase binding
Process(es)
MAPK cascade dendritic cell chemotaxis calcium ion transport chemotaxis inflammatory response immune response cellular defense response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum fusion of virus membrane with host plasma membrane calcium-mediated signaling signaling entry into host cell chemokine-mediated signaling pathway response to cholesterol cellular response to lipopolysaccharide inflammatory response to antigenic stimulus defense response aging response to ionizing radiation positive regulation of gene expression positive regulation of cell-cell adhesion negative regulation of cell migration negative regulation of axon extension forebrain development positive regulation of fever generation response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production defense response to bacterium fat cell differentiation positive regulation of neuron differentiation positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response leukocyte migration positive regulation of apoptotic process by virus neuron death positive regulation of cell migration involved in sprouting angiogenesis negative regulation of macrophage apoptotic process negative regulation of neural precursor cell proliferation
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