Invitrogen

CCR1 Polyclonal Antibody

Name: CCR1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-78946

View all (20) CCR1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

FIGURE: 1 / 1

CCR1 Antibody (PA5-78946) in WB

Western blot analysis of CCR1 in Lane 1: rat PC-12 whole cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CCR1 polyclonal antibody (Product # PA5-78946) at a dilution of 0.5 µg/mL (overnight at 4°C), followed by goat anti-rabbit IgG-HRP secondary an... View More

Product Image Gallery

Immunogen image

Immunogen Image CCR1 Polyclonal Antibody

Product Details

PA5-78946

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1-0.5 µg/mL

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived mouse CCR1 recombinant protein (Position: A168-T339).

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2746062

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat PC-12 whole cell.

Target Information

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C) receptor 1; Macrophage inflammatory protein 1-alpha receptor; macrophage inflammatory protein-1 alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES-R

View more View less

Gene Aliases: Ccr1; Cmkbr1; Mip-1a-R

View more View less

UniProt ID: (Mouse) P51675

View more View less

Entrez Gene ID: (Mouse) 12768, (Rat) 57301

View more View less

Function(s)

phosphatidylinositol phospholipase C activity signal transducer activity G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 7 binding chemokine (C-C motif) ligand 5 binding

Process(es)

calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling metabolic process negative regulation of gene expression myeloid cell differentiation positive regulation of cell migration negative regulation of bone mineralization leukocyte chemotaxis positive regulation of osteoclast differentiation negative regulation of innate immune response positive regulation of calcium ion transport chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cerebellum development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

CCR1 Polyclonal Antibody

CCR1 Antibody (PA5-78946) in WB

Product Details

PA5-78946

Western Blot (WB)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!