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Osenses
CACNA1H, CACNA1G Polyclonal Antibody
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Product Details
OSC00114G-500UG
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 95% identity with the corresponding sequences in rat and mouse.
Specificity of this antibody: CACNA1H and CACNA1G.
Target Information
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.1c; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; NBR13; T-type Cav3.2; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent calcium channel alpha 1G subunit, isoform 11; voltage-dependent T-type calcium channel alpha 1G subunit; Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.1; Voltage-gated calcium channel subunit alpha Cav3.2
Gene Aliases: [a]1G; a1G; alpha-1G; alpha13.2; Ca(V)T.1; CACNA1G; CACNA1H; CACNA1HB; Cav3.1; Cav3.1d; Cav3.2; ECA6; EIG6; KIAA1123; mKIAA1123; MNCb-1209; NBR13; SCA42
UniProt ID: (Human) O43497, (Human) O95180, (Rat) Q9EQ60
Entrez Gene ID: (Human) 8913, (Human) 8912, (Rat) 29717, (Mouse) 12291, (Rat) 114862, (Mouse) 58226
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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