OriGene

C-Jun Monoclonal Antibody (UMAB67), UltraMAB™

View all (146) c-Jun antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

UM800011

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

UMAB67

Immunogen

Full length human recombinant protein of human JUN produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activator protein 1; AH119; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; cjun; enhancer-binding protein AP1; immediate early; Jun A; Jun activation domain binding protein; Jun oncogene; jun proto-oncogene; JUND; p39; Proto-oncogene c-Jun; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog

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Gene Aliases: AP-1; AP1; c-Jun; JUN; Junc; Rjg-9

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UniProt ID: (Human) P05412, (Rat) P17325, (Mouse) P05627

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Entrez Gene ID: (Dog) 609429, (Human) 3725, (Rat) 24516, (Mouse) 16476

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity GTPase activator activity protein binding transcription factor binding enzyme binding cAMP response element binding identical protein binding protein homodimerization activity transcription regulatory region DNA binding poly(A) RNA binding protein heterodimerization activity R-SMAD binding HMG box domain binding double-stranded DNA binding sequence-specific DNA binding
Process(es)
angiogenesis microglial cell activation release of cytochrome c from mitochondria liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus aging learning circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation response to radiation response to mechanical stimulus cellular process response to organic substance response to organic cyclic compound monocyte differentiation axon regeneration negative regulation of protein autophosphorylation response to lipopolysaccharide response to cytokine leading edge cell differentiation response to muscle stretch response to drug response to hydrogen peroxide positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation by host of viral transcription positive regulation by host of viral transcription positive regulation of monocyte differentiation positive regulation of DNA replication negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP regulation of cell cycle membrane depolarization SMAD protein signal transduction cellular response to calcium ion negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Ras protein signal transduction positive regulation of epithelial cell migration regulation of cell death cellular response to hormone stimulus Fc-epsilon receptor signaling pathway regulation of cell proliferation positive regulation of GTPase activity positive regulation of cell differentiation regulation of sequence-specific DNA binding transcription factor activity eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of DNA-templated transcription, initiation negative regulation of transcription from RNA polymerase II promoter
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