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Invitrogen
Brevican Polyclonal Antibody
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Product Details
PA5-52477
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
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RRID
Product Specific Information
Immunogen sequence: ACYGDMDGFP GVRNYGVVDP DDLYDVYCYA EDLNGELFLG DPPEKLTLEE ARAYCQERGA EIATTGQLYA AWDGGLDHCS PGWLADGSVR YPIVTPSQRC GGGLPGVKTL FLFPNQTGFP NKHSRFNVYC FR
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
Target Information
Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: BEHAB; Brain-enriched hyaluronan-binding protein; Brevican core protein; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB
Gene Aliases: BCAN; BEHAB; CSPG7; UNQ2525/PRO6018
UniProt ID: (Human) Q96GW7
Entrez Gene ID: (Human) 63827
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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