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OriGene

Beta-catenin Monoclonal Antibody (OTI6A3), TrueMAB™

View all (238) beta Catenin antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite Beta-catenin Monoclonal Antibody (OTI6A3), TrueMAB™

  • Antibody Testing Data (9)
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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FIGURE: 1 / 9

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Beta-catenin Antibody (TA502337) in IHC (P)

Immunohistochemical staining of paraffin-embedded human endometrium tissue within the normal limits using anti-CTNNB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, TA502337) {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Beta-catenin Antibody in Western Blot (WB)
Beta-catenin Antibody in Western Blot (WB)
Beta-catenin Antibody in Flow Cytometry (Flow)
Beta-catenin Monoclonal Antibody (OTI6A3), TrueMAB™

Product Details

TA502337

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Flow Cytometry (Flow)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI6A3

Immunogen

Full length human recombinant protein of human CTNNB1 produced in HEK293T cell.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bcatenin; beta 1 88kDa; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; β catenin; βcatenin

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Gene Aliases: armadillo; CTNNB; CTNNB1; MRD19; OK/SW-cl.35; PRO2286

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UniProt ID: (Human) P35222

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Entrez Gene ID: (Human) 1499

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Function(s)
RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity signal transducer activity protein binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding protein phosphatase binding estrogen receptor binding protein complex binding ionotropic glutamate receptor binding nuclear hormone receptor binding transcription regulatory region DNA binding ion channel binding alpha-catenin binding cadherin binding SMAD binding androgen receptor binding nitric-oxide synthase binding I-SMAD binding repressing transcription factor binding cadherin binding involved in cell-cell adhesion euchromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter embryonic axis specification patterning of blood vessels branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second cell fate specification endodermal cell fate commitment neuron migration epithelial to mesenchymal transition neural plate development liver development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated cell adhesion cell-matrix adhesion Wnt signaling pathway, calcium modulating pathway chemical synaptic transmission ectoderm development glial cell fate determination midgut development negative regulation of cell proliferation anterior/posterior axis specification dorsal/ventral axis specification proximal/distal pattern formation positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Schwann cell proliferation response to activity Wnt signaling pathway single organismal cell-cell adhesion stem cell population maintenance layer formation in cerebral cortex central nervous system vasculogenesis osteoclast differentiation androgen receptor signaling pathway male genitalia development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol positive regulation of type I interferon production T cell differentiation in thymus negative regulation of protein sumoylation response to cytokine adherens junction assembly protein localization to cell surface embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hair cell differentiation catenin import into nucleus embryonic skeletal limb joint morphogenesis regulation of T cell proliferation odontogenesis of dentin-containing tooth response to drug embryonic digit morphogenesis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of neuron apoptotic process response to estrogen canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition canonical Wnt signaling pathway involved in negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus myoblast differentiation bone resorption positive regulation of endothelial cell differentiation positive regulation of osteoblast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic response to cadmium ion chromatin-mediated maintenance of transcription regulation of fibroblast proliferation cell maturation synaptic vesicle transport thymus development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis negative regulation of oligodendrocyte differentiation regulation of neurogenesis synapse organization positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization positive regulation of histone H3-K4 methylation positive regulation of telomerase activity oviduct development canonical Wnt signaling pathway trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development cranial ganglion development regulation of centromeric sister chromatid cohesion cellular response to mechanical stimulus cellular response to lithium ion cellular response to growth factor stimulus cellular response to indole-3-methanol renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import negative regulation of neuron death positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding regulation of core promoter binding beta-catenin-TCF complex assembly beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation cellular response to insulin-like growth factor stimulus embryonic brain development dorsal root ganglion development regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of DNA-templated transcription, initiation negative regulation of apoptotic signaling pathway
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