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Proteintech
BDNF Monoclonal Antibody (1E5C5)
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Product Details
66292-1-IG
Species Reactivity
Published species
Host/Isotype
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Type
Clone
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: MKEANIRGQ GGLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHMIEE LLDEDQKVRP NEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDSKKRIGWR FIRIDTSCVC TLTIKRGR (21-247 aa encoded by BC029795 )
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Abrineurin; Brain-derived neurotrophic factor; H-BDNF; Neurotrophic factor BDNF precursor form; neurotrophin; proBDNF
Gene Aliases: ANON2; BDNF; BULN2
UniProt ID: (Human) P23560
Entrez Gene ID: (Human) 627
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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