Invitrogen

BBS4 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
BBS4 Polyclonal Antibody

Product Details

PA5-78617

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human BBS4. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735516

Product Specific Information

Positive Control: Neuro2A, C8D30, NIH-3T3, rat colon

Predicted Reactivity: Human (100%), Pig (92%), Chimpanzee (98%), Bovine (91%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bardet-Biedl syndrome 4 homolog; Bardet-Biedl syndrome 4 protein; Bardet-Biedl syndrome 4 protein homolog; BBSome complex member BBS4

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Gene Aliases: AW537059; AW742241; BBS4; D9Ertd464e

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UniProt ID: (Human) Q96RK4, (Mouse) Q8C1Z7

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Entrez Gene ID: (Human) 585, (Mouse) 102774, (Rat) 300754

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Function(s)
RNA polymerase II repressing transcription factor binding microtubule motor activity protein binding dynactin binding alpha-tubulin binding beta-tubulin binding molecular_function
Process(es)
microtubule cytoskeleton organization mitotic cytokinesis neural tube closure retina homeostasis negative regulation of systemic arterial blood pressure transport spermatid development sensory perception of smell protein localization metabolic process negative regulation of gene expression protein transport dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior negative regulation of actin filament polymerization regulation of cytokinesis leptin-mediated signaling pathway protein localization to organelle negative regulation of GTPase activity microtubule anchoring at centrosome nonmotile primary cilium assembly social behavior photoreceptor cell outer segment organization negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth cilium assembly response to leptin photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development brain morphogenesis centrosome organization maintenance of protein location in nucleus regulation of stress fiber assembly cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility face development fat pad development protein localization to cilium protein localization to centrosome regulation of nonmotile primary cilium assembly protein localization to photoreceptor outer segment neuron migration heart looping visual perception melanosome transport fat cell differentiation intracellular transport sensory processing biological_process
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