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Invitrogen
B7-H4 Polyclonal Antibody
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FIGURE: 1 / 1
B7-H4 Antibody (PA5-87879) in WB
Product Details
PA5-87879
Species Reactivity
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Product Specific Information
Immunogen sequence: RTAVFADQVI VGNASLRLKN VQLTDAGTYK CYIITSKGKG NANLEYKTGA FSMPEVNVDY NASSETLRCE APRWFPQPTV VWASQVDQGA NFSEVSNTSF ELNSENVTMK VVSVLYNVTI NNTYSCMIEN DIAKATGDIK VTESEIKRRS HLQLLNSKAS L; Positive Samples: MCF-7, SKOV3, HeLa, 293T, B-cell, Mouse uterus, Rat thymus; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7-H4; B7h.5; FLJ22418; Immune costimulatory protein B7-H4; Protein B7S1; RP11-229A19.4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; VTCN1; vtcn1 {ECO:0000312|EMBL:AAH95842.1}
Gene Aliases: B7-H4; B7h.5; B7H4; B7S1; B7X; BC032925; PRO1291; RGD1311204; UNQ659/PRO1291; VCTN1; VTCN1
UniProt ID: (Human) Q7Z7D3, (Rat) Q501W4, (Mouse) Q7TSP5
Entrez Gene ID: (Human) 79679, (Rat) 295322, (Mouse) 242122
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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