OriGene

B2M Monoclonal Antibody (OTI1A7), TrueMAB™

View all (92) beta-2 Microglobulin antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
B2M Monoclonal Antibody (OTI1A7), TrueMAB™

Product Details

TA803617

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI1A7

Immunogen

Human recombinant protein fragment corresponding to amino acids 21-119 of human B2M produced in SF9 cell.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m

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Gene Aliases: B2M; CDABP0092; HDCMA22P; IMD43

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UniProt ID: (Human) P61769

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Entrez Gene ID: (Human) 567

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Function(s)
glycoprotein binding protein binding identical protein binding
Process(es)
retina homeostasis positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent positive regulation of T cell cytokine production regulation of membrane depolarization negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of protein binding T cell differentiation in thymus protein refolding response to drug cellular protein metabolic process innate immune response response to cadmium ion positive regulation of receptor-mediated endocytosis regulation of defense response to virus by virus regulation of immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium iron ion homeostasis interferon-gamma-mediated signaling pathway cellular response to lipopolysaccharide cellular response to iron ion negative regulation of receptor binding positive regulation of receptor binding positive regulation of ferrous iron import into cell positive regulation of ferrous iron binding positive regulation of transferrin receptor binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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