Invitrogen

Aurora A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Aurora A Polyclonal Antibody

Product Details

PA5-86309

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 251-300 of Human AURKA.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803092

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora-A; aurora-related kinase 1; aurora/IP; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1

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Gene Aliases: AIK; AIRK1; ARK-1; ARK1; AU019385; AURA; AURKA; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; PPP1R47; STK15; STK6; STK7

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UniProt ID: (Human) O14965, (Mouse) P97477

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Entrez Gene ID: (Human) 6790, (Mouse) 20878, (Rat) 261730

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding ubiquitin protein ligase binding histone serine kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle protein phosphorylation cell cycle spindle organization mitotic spindle organization spindle assembly involved in female meiosis I mitotic nuclear division mitotic centrosome separation meiotic nuclear division anterior/posterior axis specification phosphorylation cell projection organization regulation of protein stability negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis histone-serine phosphorylation negative regulation of apoptotic process centrosome organization cell division centrosome localization protein localization to centrosome negative regulation of spindle checkpoint positive regulation of oocyte maturation neuron projection extension response to estradiol G2/M transition of mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest anaphase-promoting complex-dependent catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of mitotic nuclear division regulation of centrosome cycle protein autophosphorylation regulation of signal transduction by p53 class mediator
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