Invitrogen

Aquaporin 1 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Aquaporin 1 Polyclonal Antibody

Product Details

PA5-120324

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-269 of human Aquaporin-1 (AQP1) (NP_9327661)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.46 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913896

Product Specific Information

Positive test controls include: Mouse liver, Mouse heart, Rat lung. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.

Immunogen sequence: AVITHNFSNH WIFWVGPFIG GALAVLIYDF ILAPRSSDLT DRVKVWTSGQ VEEYDLDADD INSRVEMKPK

Target Information

Aquaporin 1 is a 28kD integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AQP 1; AQP CHIP; AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group); aquaporin 1, Colton blood group antigen; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel-like integral membrane protein of 28 kDa; channel-like integral membrane protein, 28-kDa; CHIP 28; Colton blood group; Delayed early response protein 2; DER2; growth factor-induced delayed early response protein; MGC26324; Urine water channel; water channel protein for red blood cells and kidney proximal tubule

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Gene Aliases: AQP-CHIP; AQP1; CHIP28; CO

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UniProt ID: (Human) P29972, (Mouse) Q02013, (Rat) P29975

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Entrez Gene ID: (Human) 358, (Mouse) 11826, (Rat) 25240

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Function(s)
intracellular cGMP activated cation channel activity potassium channel activity water transmembrane transporter activity protein binding ammonium transmembrane transporter activity potassium ion transmembrane transporter activity glycerol transmembrane transporter activity water channel activity glycerol channel activity transmembrane transporter activity nitric oxide transmembrane transporter activity carbon dioxide transmembrane transporter activity transporter activity ephrin receptor binding
Process(es)
renal water homeostasis renal water transport cGMP biosynthetic process potassium ion transport water transport cell volume homeostasis cellular water homeostasis carbon dioxide transport ammonium transport bicarbonate transport glycerol transport cellular homeostasis lateral ventricle development pancreatic juice secretion nitric oxide transport establishment or maintenance of actin cytoskeleton polarity cerebrospinal fluid secretion cellular response to stress cellular response to UV transepithelial water transport carbon dioxide transmembrane transport odontogenesis response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis positive regulation of saliva secretion positive regulation of fibroblast proliferation multicellular organismal water homeostasis cellular response to hydrogen peroxide cellular response to inorganic substance cellular response to mechanical stimulus cellular response to copper ion cellular response to mercury ion cellular response to retinoic acid cellular response to cAMP cellular response to hypoxia cellular response to salt stress cellular hyperosmotic response cellular response to dexamethasone stimulus cellular response to nitric oxide potassium ion transmembrane transport ammonium transmembrane transport maintenance of symbiont-containing vacuole by host glomerular filtration transport positive regulation of lamellipodium assembly positive regulation of epithelial cell migration organic cation transport sensory perception of pain water homeostasis positive regulation of cell migration secretion by cell secretory granule organization carbohydrate transmembrane transport wound healing lipid digestion camera-type eye morphogenesis corticotropin secretion transmembrane transport renal water absorption cation transmembrane transport hyperosmotic response response to hormone hyperosmotic salinity response response to estrogen metanephric descending thin limb development metanephric proximal straight tubule development metanephric proximal convoluted tubule segment 2 development metanephric glomerulus vasculature development
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