Invitrogen

Activin A Recombinant Rabbit Monoclonal Antibody (1X6N9)

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Datasheet
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Datasheet
Protocols
Questions & Answers
Activin A Recombinant Rabbit Monoclonal Antibody (1X6N9)

Product Details

MA5-42875

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1X6N9

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Inhibin beta A (INHBA) (P08476).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912016

Product Specific Information

Positive test controls include: HeLa, Mouse uterus, Rat testis. The target is usually found in the following locations: Secreted.

Immunogen sequence: MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A; Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1

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Gene Aliases: EDF; FRP; INHBA

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UniProt ID: (Human) P08476, (Rat) P18331, (Mouse) Q04998

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Entrez Gene ID: (Human) 3624, (Rat) 29200, (Mouse) 16323

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Function(s)
cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity peptide hormone binding inhibin binding identical protein binding protein heterodimerization activity type II activin receptor binding receptor binding
Process(es)
G1/S transition of mitotic cell cycle ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter cell cycle arrest negative regulation of cell proliferation male gonad development positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway endodermal cell differentiation growth odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion regulation of apoptotic process regulation of MAPK cascade positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development palate development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand defense response cell surface receptor signaling pathway cell-cell signaling nervous system development positive regulation of gene expression striatal medium spiny neuron differentiation cell differentiation erythrocyte differentiation negative regulation of phosphorylation negative regulation of interferon-gamma biosynthetic process negative regulation of B cell differentiation negative regulation of macrophage differentiation positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion GABAergic neuron differentiation negative regulation of hair follicle development
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