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Invitrogen
ATG4B Polyclonal Antibody
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Product Details
PA5-114497
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Positive controls that may be used include: Ramos Cell Lysate, Jurkat Cell Lysate, Human Spleen Tissue Lysate, Human Spleen Tissue Slide
Target Information
Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; Autophagin-1; autophagy related 4 homolog B; autophagy related 4B, cysteine peptidase; autophagy-related 4B; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; HsAPG4B; MmAPG4B
Gene Aliases: 2510009N07Rik; APG4B; ATG4B; Atg4bl; AUTL1; AW048066; KIAA0943
UniProt ID: (Human) Q9Y4P1, (Mouse) Q8BGE6, (Rat) A0A0G2QC33
Entrez Gene ID: (Human) 23192, (Mouse) 66615, (Rat) 316640
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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