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  • ASIC2 Antibodies

Osenses

ASIC2 Polyclonal Antibody

1 Reference
View all (14) ASIC2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite ASIC2 Polyclonal Antibody

ASIC2 Polyclonal Antibody

Product Details

OSA00066G-500UG

Applications
Tested Dilution
Publications

Western Blot (WB)

10-50 µg/mL
-

Immunohistochemistry (IHC)

10-50 µg/mL
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 470-503 of human ASIC2 conjugated to blue carrier protein was used as the antigen
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in rat and mouse.

Specificity of this antibody: ASIC2.

Target Information

ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1

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Gene Aliases: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNaC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2

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UniProt ID: (Human) Q16515, (Rat) Q62962, (Mouse) Q925H0

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Entrez Gene ID: (Human) 40, (Rat) 25364, (Mouse) 11418

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Function(s)
protein binding ligand-gated sodium channel activity ion gated channel activity acid-sensing ion channel activity ion channel activity voltage-gated sodium channel activity cation channel activity sodium channel activity
Process(es)
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback cation transport sodium ion transport phototransduction sensory perception of sound response to mechanical stimulus response to acidic pH regulation of gene expression regulation of vasoconstriction regulation of blood coagulation ion transmembrane transport regulation of ion transmembrane transport protein localization to synapse cellular response to drug sodium ion transmembrane transport regulation of membrane potential negative regulation of apoptotic process sensory perception of sour taste detection of mechanical stimulus involved in sensory perception positive regulation of synapse assembly cellular response to acidic pH cation transmembrane transport positive regulation of cation channel activity chemical synaptic transmission central nervous system development peripheral nervous system development monovalent inorganic cation transport transport ion transport
It has to be done as per old AB suggested Products section.
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